Nicorandil reduced coronary events in stable angina.

P a t i e n t s 5126 patients (mean age 67 y, 76% men) who had stable angina with a history of myocardial infarction (MI), coronary bypass surgery, a definite diagnosis (by angiography) of coronary heart disease (CHD), or a documented positive result on the exercise test. Patients with CHD or a positive result on the exercise test were also required to have additional risk factors, including left ventricular ejection fraction ≤ 45%, echocardiographic end-diastolic dimension > 55 mm, and type 1 or type 2 diabetes. Patients receiving treatment with a sulfonylurea were excluded. Follow-up was 100%.